Non-human Primate (Rhesus) CD3+ Pan T Cells
Non-human Primates (NHP) are the closest phylogenic relatives to man. They are often indispensable in biomedical and psychological research. The rhesus monkey is the most widely used laboratory primate. They are a small, Asian old world monkey which are often used in research due to ease of rearing in captivity. Rhesus monkeys can thrive in a variety of climates and habitats. They measure about 47–64 cm (19–25 inches) long, excluding the furry 20–30-cm tail. Females average about 8.5 kg (19 pounds) and males 11 kg. Rhesus monkeys live in groups consisting of several adults of both sexes and their young; males leave the troop at maturity, whereas females tend to stay in the troops in which they were born. Sexual maturity occurs between two and three years of age.
Most T cell lineages express surface protein CD3, which is made of invariant subchains belonging to the immunoglobulin superfamily. CD3 is a multimeric protein complex, which is composed of four distinct chains (CD3g, CD3d and two CD3e). CD3 on the cell surface associated with the T-cell antigen receptor (TCR) functions in the signaling transduction cascade that originates when a peptide - MHC ligand binds to the TCR.
Rhesus CD3+ Pan T cells can be subdivided further into NK cells, CD8+ cytotoxic T cells and CD4+ helper T cells. T cells are used to perform research in immunology as well as oncology and infectious diseases.
Our Non Human Primate CD3+ Pan T Cells are isolated from Non Human Primate mononuclear cells by negative selection. All Non-Human Primate whole blood is collected by venipuncture from animals housed within the United States.