Type 2 Diabetes Leuko Pak / Whole Blood / Plasma

Type 2 diabetes mellitus (T2DM) accounts for vast majority of hyperglycemia (high levels of blood glucose). It is a chronic metabolic disorder that is caused by a resistance to and relative deficiency of Insulin. Chronic uncontrolled hyperglycemia can lead to serious problems with the heart, eyes, kidneys, nerves, and gums and teeth. Development of T2DM is primarily due to genetics and life style factors. Individuals with diagnosed relatives have a much higher risk of developing T2DM themselves. A number of genes have been associated with increased risk of T2DM, including TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, and HHEX. KCNJ11 TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, and HHEX. Life style factors including inactivity, smoking and generous alcohol consumption all have been linked to the development of the condition. Obesity has been found to contribute to approximately 55% of cases of T2DM.

Leuko paks are obtained when patients become available to our network of clinicians, by a donation process where blood is withdrawn from the donor via leukapheresis utilizing an apheresis machine such as the COBE Spectra Optia®. The donor’s white blood cells are selectively collected and the remaining blood is reinfused to the body.  We can also collect whole blood and plasma samples from the patients. Some disease types may have a long backorder depending on the frequency of the disease occurrence in the general population.

HumanCells’ Type 2 Diabetes products are obtained from patient donors who are fully consented and IRB approved.