Type 1 Diabetes Leuko Pak / Whole Blood / Plasma
Type 1 diabetes mellitus(T1DM) is an autoimmune disease characterized by insulin deficiency due to pancreatic beta-cell loss. It represents around 10% of the diabetes cases worldwide. The age of symptomatic onset of T1DM is often childhood or adolescence, and the onset has nothing to do with diet or lifestyle. The cause of T1DM is not well understood but it is believed to be T cell mediated beta-cell destruction or damaging. T1DM might develop in susceptible individuals when certain environmental factors exist. A number of genes have been linked to susceptibility to T1DM, including HLA, insulin, PTPN22, IL2Ra, and CTLA4. Autoantiboeis targeting beta cells can often be detected months to years before symptom onset and can be used as biomarkers to identify people at risk of developing T1DM.
Leuko paks are obtained when patients become available to our network of clinicians, by a donation process where blood is withdrawn from the donor via leukapheresis utilizing an apheresis machine such as the COBE Spectra Optia®. The donor’s white blood cells are selectively collected and the remaining blood is reinfused to the body. We can also collect whole blood and plasma samples from the patients. Some disease types may have a long backorder depending on the frequency of the disease occurrence in the general population.
HumanCells’ Type 1 Diabetes products are obtained from patient donors who are fully consented and IRB approved.