Human Normal Peripheral Blood CD14+ Monocytes
Monocytes are often referred to as CD14+ monocytes, because of their expression of CD14. Monocytes make up between three to 8% of the leukocytes in the blood. Monocytes migrate from the bloodstream to other tissues and then differentiate into macrophages or dendritic cells. Monocytes and their macrophage and dendritic cell progeny serve three main functions, namely phagocytosis, antigen presentation, and cytokine production, in the immune system.
Our Human Normal Peripheral Blood CD14+ Monocytes are isolated from peripheral blood mononuclear cells by either positive or negative immunomagnetic selection, depending upon your needs. All peripheral blood is collected in acid-citrate-dextrose formula A (ACDA) by leukapheresis from fully consented IRB approved donors that are tested negative for HIV, HBV, and HCV.
1. Loems Ziegler-Heitbrock and Thomas P. J. Hofer. Toward a refined definition of monocyte subsets. Front. Immunol., 04 February 2013