Mobilized Peripheral Blood Mononuclear Cells (PBMCs)

Mobilized human peripheral blood MNCs, PBMCs

Human Peripheral Blood Mononuclear Cells (PBMC) are blood cells with a single round nucleus. These cells include lymphocytes (T, B and NK cells), monocytes and dendritic cells.  Mononuclear cells are parts of the immune system which is critical for cell-mediated and humoral immunity. 

Mobilized peripheral blood is collected after the donor is treated with mobilization agent such as G-CSF or Plerixafor. Such treatment mobilizes blood stem cells that are normally reside in the bone marrow to enter the blood stream. The content of CD34+ stem cells in the blood is therefore the most important parameter of graft quality. The optimal CD34+ cell dose is widely accepted to be 5 × 106/kg. Particularly, the more primitive CD34+/CD38- subset has been shown to have high self-renewal and repopulation capability. Stem cell mobilization also affects the properties of other components of the graft such as T lymphocytes and NK cells.

 

HumanCellsBio Human Mobilized PBMCs are isolated from healthy donors that have been mobilized with GCSF collected in acid-citrate-dextrose formula A (ACDA) as an anticoagulant.   All donors must be tested negative for HBV, HCV and HIV and are IRB consented.

Mobilized human Peripheral Blood Mononuclear Cells (PBMCs)

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Catalog# Format Product name Size Price Quantity  
MPBMC-C200M Frozen Mobilized Peripheral Blood Mononuclear Cells (PBMCs) 200 million
$799.00
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MPBMC-F100M Fresh Mobilized Peripheral Blood Mononuclear Cells (PBMCs) 100 million
$599.00
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MPBMC-C100M Frozen Mobilized Peripheral Blood Mononuclear Cells (PBMCs) 100 million
$499.00
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MPBMC-F500M Fresh Mobilized Peripheral Blood Mononuclear Cells (PBMCs) 500 million
$1,299.00
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MPBMC-F300M Fresh Mobilized Peripheral Blood Mononuclear Cells (PBMCs) 300 million
$899.00
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